Intitulé du sujet: The Overlap of Sleep Apnea and ADHD: Unraveling Behavioral and Cognitive Pathways in Pediatric Populations
Sujet
Codirection: FEFEU Mylene
Nombre de mois: 48 mois
Ecole Doctorale: ED 158 - Cerveau, Cognition, Comportement
Unité de recherche et équipe:
INSERM
UMR 1141 NeuroDiderot
Equipe NeoPhen/SleepCMD
Hôpital Robert Debré
Coordonnées de l’équipe:
Chef d’équipe
Christophe Delclaux, Service de Physiologie - Explorations fonctionnelles, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris
Boris Matrot, Inserm UMR1141, Hôpital Robert Debré, 48 boulevard Sérurier, 75019 Paris
La prise en charge et le traitement des troubles respiratoires liés au sommeil est un enjeu important de santé publique, notamment pendant la période néonatale. Récemment, des découvertes importantes ont été effectuées pour identifier les structures neurologiques de la génération du rythme respiratoire chez la souris, ouvrant la voie au développement de nouveaux outils de diagnostic et de traitement. De plus, au cours des dernières années au niveau clinique, de nouveaux outils de traitement avancé des signaux physiologiques ont été développés. L’équipe a été rejointe en 2020 et 2021 par un enseignant chercheur psychiatre (P Geoffroy) et une chercheuse INSERM (K Spruyt) permettant d’étendre le champ de nos recherches aux troubles de l’humeur et rythmes biologiques ainsi qu’aux conséquences des troubles du sommeil (notamment liés aux apnées du sommeil et aux troubles de l’humeur) sur le neuro-développement de l’enfant.
http://neurodiderot.org/index.php/neophen/
Secteur: Sciences Sociales et Humanités / Social Sciences and Humanities
Langue attendue: Anglais
Niveau de langue attendu: C2
Description
Description du sujet:
Obstructive sleep apnea (OSA), a prevalent sleep-disordered breathing condition in children, affects 1.1%–20.4% of the global pediatric population, with increasing prevalence in preschool-aged and obese children (Magnusdottir S, et al 2024). OSA disrupts sleep and neurodevelopment, contributing to behavioral and cognitive impairments associated with changes in the prefrontal cortex (Spruyt K, 2019; Lo Bue et al 2020) . Common symptoms include snoring, mouth breathing, and hyperactivity, with polysomnography (PSG) recognized as the diagnostic gold standard. Attention-deficit/hyperactivity disorder (ADHD), affecting approximately 5.9% of children(Van Vyve et al 2024), shares overlapping behavioral symptoms with OSA, such as hyperactivity and inattention. ADHD is characterized by persistent inattention and impulsivity, often accompanied by psychiatric comorbidities. Investigating the intersection of OSA and ADHD may uncover shared mechanisms, enhance diagnostic precision, and support the development of interdisciplinary interventions to improve pediatric neurodevelopmental outcomes. This study aims to identify children with OSA through PSG and assess the prevalence and characteristics of comorbid ADHD using a standardized evaluation tool. It further seeks to analyze the relationship between PSG-derived objective sleep parameters—including the apnea-hypopnea index (AHI), minimum and average blood oxygen saturation, sleep efficiency, total sleep duration, sleep architecture, and sleep latency—and ADHD. Additionally, it explores the association between OSA and ADHD by examining relevant blood markers. Understanding the prevalence of ADHD in children with OSA will advance medical knowledge, facilitate earlier diagnosis, and support timely interventions. Investigating the relationship between sleep metrics and ADHD symptoms provides critical insights into the influence of sleep disturbances on ADHD, offering a foundation for improved clinical practices. Finally, exploring the role of blood markers addresses research gaps and fosters the translation of findings into clinical applications, contributing to better diagnostic, therapeutic, and preventive strategies that enhance the overall quality of life for affected children.
Compétences requises:
- Ability to work in a team and/or in an interdisciplinary context
- Analytical, synthesis, and written expression skills
- Intellectual curiosity and appropriate initiative
- Skills in statistical software, e.g., SPSS, R, SAS, or others
- Skills in Microsoft Office programs, e.g., excel
Références bibliographiques:
MAGNUSDOTTIR S, HILL E A. Prevalence of obstructive sleep apnea (OSA) among preschool aged children in the general population: A systematic review[J/OL]. Sleep Medicine Reviews, 2024, 73: 101871
SPRUYT K. A review of developmental consequences of poor sleep in childhood. Sleep Med. 2019 Aug;60:3-12. doi: 10.1016/j.sleep.2018.11.021.
LO BUE A, SALVAGGIO A, INSALACO G. Obstructive sleep apnea in developmental age. A narrative review[J/OL]. European Journal of Pediatrics, 2020, 179(3): 357-365.
VAN VYVE L, DIERCKX B, LIM C G, et al. Pharmacotherapy for ADHD in children and adolescents: A summary and overview of different European guideline. European Journal of Pediatrics, 2024, 183(3): 1057
