Intitulé du sujet: Multiscale modeling of soft fibrous tissue
Sujet
Codirection: Oui
Nombre de mois: 48 mois
Ecole Doctorale: ED 561 - Hématologie, Oncogénèse et Biothérapies
Unité de recherche et équipe:
The laboratory of Osteoarticular Biology, Bioengineering and Bioimaging (B3OA) UMR CNRS 7052 INSERM U1271 is affiliated with the CNRS Ingénierie , with the INSERM , with the Paris Cité University and with the Ecole Nationale Vétérinaire de Maisons-Alfort . Since its creation in 1977, the laboratory has developed a renowned expertise in repair and imaging of skeletal tissues. Based on its experience, the B3OA’s mission is to deliver world-class research and education on osteo-articular bioengineering and imaging.
Coordonnées de l’équipe:
B3OA, UMR 7052, Faculté de Médecine Lariboisière Saint Louis, 10 avenue de Verdun, 75010 Paris, email : thierry.hoc@cnrs.fr
Secteur: Sciences Physiques et Ingénierie / Physical sciences and Engineering
Langue attendue: Anglais
Niveau de langue attendu: B1
Description
Description du sujet:
The main aim of the proposed thesis is to develop a mechanical behavior law for collagenous fibrous soft tissues. The subject is purely numerical, and requires the candidate to have a keen interest in computer science and numerical simulation. The subject can be divided into three parts: First, a bibliography to better understand the numerical models of behavior laws in large transformations and the components of collagen and their assembly. Secondly, models taking into account aspects of tissue anisotropy and viscoelasticity will be developed and implemented in finite element codes. Finally, these models will be used to study the degradation of these tissues in relation to pathologies (osteoporosis, arthrosis) or aging.
Compétences requises:
Hard skills: Mechanical engineering; Finite element simulation; Mechanical behavior, Continuum mechanics.
Soft Skills : Curious and autonomous,
Références bibliographiques:
Zhuang Xiong, Léa Rouquier, Xingrong Huang, Esther Potier, Morad Bensidhoum, Thierry Hoc,Porosity and surface curvature effects on the permeability and wall shear stress of trabecular bone: Guidelines for biomimetic scaffolds for bone repair, Computers in Biology and Medicine, Volume 177, 2024, 108630, ISSN 0010-4825,https://doi.org/10.1016/j.compbiomed.2024.108630.
Laure Astruc, Annie Morch, Jean-François Witz, Vít Nováček, Frédéric Turquier, Thierry Hoc, Mathias Brieu, An anisotropic micro-ellipsoid constitutive model based on a microstructural description of fibrous soft tissues, Journal of the Mechanics and Physics of Solids, Volume 131, 2019, Pages 56-73, ISSN 0022-5096, https://doi.org/10.1016/j.jmps.2019.06.019.
Sarah Pragnère, Caroline Boulocher, Ophélie Pollet, Catherine Bosser, Aurélie Levillain, Magali Cruel, Thierry Hoc, Mechanical alterations of the bone-cartilage unit in a rabbit model of early osteoarthrosis, Journal of the Mechanical Behavior of Biomedical Materials, Volume 83, 2018, Pages 1-8, ISSN 1751-6161, https://doi.org/10.1016/j.jmbbm.2018.03.033.
